Retatrutide
Also known as: Triple-G, GGG agonist, LY3437943
Summary
An investigational triple agonist (GIP/GLP-1/glucagon) showing large weight-loss effects in trials.
How it works
Activates three incretin/energy-balance receptors — GIP, GLP-1, and glucagon — combining appetite suppression with increased energy expenditure.
What it’s studied for
- Large weight reduction in phase-2 trials
- Triple-receptor mechanism
- Strong metabolic effects
Research-reported protocol
Clinical trials titrate weekly subcutaneous doses upward over months; it is investigational and not yet approved.
Route: Subcutaneous (weekly). These are amounts described in the research literature — not an instruction to administer anything.
Reconstitution — run the numbers
The same calculator the coach uses. Enter a vial size, water, and a dose to see the exact draw on a U-100 syringe.
Reconstitution
live · real mathDraw to
on a U-100 syringe
10units
2,500
mcg/mL
0.1
mL/dose
20
doses/vial
Show the math
- Concentration2,500 mcg/mL
vial mg ÷ water mL × 1,000
5 mg ÷ 2 mL × 1,000
- Volume per dose0.1 mL
dose mcg ÷ concentration
250 mcg ÷ 2,500 mcg/mL
- Units to draw10 units
mL per dose × 100
0.1 mL × 100
- Doses per vial20 doses
vial mcg ÷ dose mcg (rounded down)
5,000 mcg ÷ 250 mcg
Calculated, not guessed — the same math the app and coach use. Double-check it yourself.
The exact math, shown in the open. Full tool at the calculator.
Cautions
- Investigational; not approved
- GI side effects during titration; gray-market sourcing carries added risk
Evidence & sources
Written by Titria Research Team.
A credentialed reviewer (PhD/PharmD) and a primary-literature citation list are still being added — we show this state honestly rather than implying a review that hasn’t happened. It means the sign-off is pending, not that the entry is unsupported. See how we rate evidence.
Check the primary literature yourself — testing our labels is encouraged.
Often studied alongside
Model a Retatrutide protocol for your goals.
The coach interviews you, grounds every dose in this database and the calculator above, and saves a research protocol — never a hallucinated number.