PT-141
Also known as: Bremelanotide, Vyleesi
Summary
An FDA-approved melanocortin-receptor agonist for hypoactive sexual desire disorder in premenopausal women; studied more broadly for libido.
How it works
Activates central melanocortin receptors (MC4R) to influence sexual desire through the nervous system rather than the vascular route of PDE5 inhibitors.
What it’s studied for
- Approved for HSDD in premenopausal women
- Studied for libido in both sexes
- Central (not purely vascular) mechanism
Research-reported protocol
The approved product is studied at ~1.75 mg subcutaneously as needed before anticipated activity, with per-window and monthly limits in labelling.
Route: Subcutaneous. These are amounts described in the research literature — not an instruction to administer anything.
Reconstitution — run the numbers
The same calculator the coach uses. Enter a vial size, water, and a dose to see the exact draw on a U-100 syringe.
Reconstitution
live · real mathDraw to
on a U-100 syringe
10units
2,500
mcg/mL
0.1
mL/dose
20
doses/vial
Show the math
- Concentration2,500 mcg/mL
vial mg ÷ water mL × 1,000
5 mg ÷ 2 mL × 1,000
- Volume per dose0.1 mL
dose mcg ÷ concentration
250 mcg ÷ 2,500 mcg/mL
- Units to draw10 units
mL per dose × 100
0.1 mL × 100
- Doses per vial20 doses
vial mcg ÷ dose mcg (rounded down)
5,000 mcg ÷ 250 mcg
Calculated, not guessed — the same math the app and coach use. Double-check it yourself.
The exact math, shown in the open. Full tool at the calculator.
Cautions
- Can transiently raise blood pressure and cause nausea/flushing
- Contraindicated in uncontrolled hypertension/cardiovascular disease
- Approved product is a prescription medicine
Evidence & sources
Written by Titria Research Team.
A credentialed reviewer (PhD/PharmD) and a primary-literature citation list are still being added — we show this state honestly rather than implying a review that hasn’t happened. It means the sign-off is pending, not that the entry is unsupported. See how we rate evidence.
Check the primary literature yourself — testing our labels is encouraged.
Often studied alongside
Model a PT-141 protocol for your goals.
The coach interviews you, grounds every dose in this database and the calculator above, and saves a research protocol — never a hallucinated number.